DDX58

Probable ATP-dependent RNA helicase DDX58

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    Description

    DDX58 is an innate immune receptor with 106 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including detection of virus.

     

     

     

     

     

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    Details
    • Complete Protein Name
      Probable ATP-dependent RNA helicase DDX58
    • Gene ID
       23586
    • Uniprot ID
      O95786
    • Chromossomal Location
      9p21.1
    • RNA-binding protein
      Yes
    • Molecular Function
      ATP binding ,double-stranded DNA binding ,double-stranded RNA binding ,helicase activity ,identical protein binding ,single-stranded RNA binding ,ubiquitin protein ligase binding ,zinc ion binding
    • OMIM Disease
      Singleton-Merten syndrome
    • Used cell type
      MEFs, HeLa, 293T, HEC-1B
    • Used Stimuli
      Sodium arsenite
    • Subcellular Localization
      Cytoskeleton, Plasma membrane, Cytoplasm, tight junction
    • Reference
      Onomoto, K.; Jogi, M.; Yoo, JS.; Narita, R.; Morimoto, S.; Takemura, A.; Sambhara, S.; Kawaguchi, A.; Osari, S.; Nagata, K.; Matsumiya, T.; Namiki, H.; Yoneyama, M.; Fujita, T. (2012). Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One. 7(8):e43031
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