SQSTM1

Sequestosome-1

    view_headline
    Description

    SQSTM1 is a protein with 47 kDa. Has various molecular functions, such as protein kinase binding. Is involved in several biological processes, including autophagy.

     

     

     

     

     

    view_module
    Tags
    view_module
    Details
    • Complete Protein Name
      Sequestosome-1
    • Gene ID
      8878
    • Uniprot ID
      Q13501
    • Chromossomal Location
      5q35.3
    • RNA-binding protein
      No
    • Molecular Function
      Enzyme binding ,identical protein binding ,ionotropic glutamate receptor binding ,K63-linked polyubiquitin modification-dependent protein binding, protein homodimerization activity ,protein kinase binding ,protein kinase C binding ,protein serine/threonine kinase activity ,receptor tyrosine kinase binding,SH2 domain binding ,ubiquitin binding ,ubiquitin protein ligase binding ,zinc ion binding
    • OMIM Disease
      Frontotemporal dementia and/or amyotrophic lateral sclerosis, Myopathy, Neurodegeneration (with ataxia, dystonia, and gaze palsy), Paget disease of bone
    • Used cell type
      HeLa
    • Used Stimuli
      Heat shock
    • Subcellular Localization
      Endoplasmic reticulum, Endosome, Nucleus, Cytosol, Lysosome, autophagosome, sarcomere
    • Reference
      Mateju, D.; Franzmann, TM.; Patel, A.; Kopach, A.; Boczek, EE.; Maharana, S.; Lee, HO.; Carra, S.; Hyman, AA.; Alberti, S. (2017). An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function. EMBO J. 36(12):1669-1687
    keyboard_arrow_up