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Description
FMR1 is a polyribosome-associated RNA-binding protein with 71 kDa. Has various molecular functions, such as ribosome binding. Is involved in several biological processes, including cellular response to UV.
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Categories
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Details
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Complete Protein NameFragile X mental retardation protein
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Gene ID2332
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Uniprot IDQ06787
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Chromossomal LocationXq27.3
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RNA-binding proteinYes
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Molecular FunctionChromatin binding ,dynein complex binding ,G-quadruplex RNA binding ,identical protein binding ,ion channel binding ,methylated histone binding ,microtubule binding ,miRNA binding ,mRNA 3'-UTR binding ,mRNA 5'-UTR binding , mRNA binding ,poly(G) binding ,poly(U) RNA binding ,protein heterodimerization activity ,protein homodimerization activity ,ribosome binding ,RNA binding ,RNA stem-loop binding ,RNA strand annealing activity ,sequence-specific mRNA binding ,siRNA binding ,translation initiation factor binding ,translation repressor activity
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OMIM DiseaseFragile X syndrome, Fragile X tremor/ataxia syndrome, Premature ovarian failure
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Used cell typeHeLa
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Used StimuliSodium arsenite
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Subcellular LocalizationNucleus, Plasma membrane, centromere, Chromosome, Cytoplasm, perinuclear region, Cytoplasmic ribonucleoprotein granule, Perikaryon, Cell projection, axon, dendrite, dendritic spine, synaptosome, growth cone, filopodium tip, synapse
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ReferenceLinder B., Plöttner O., Kroiss M., Hartmann E., Laggerbauer B., Meister G., Keidel E., Fischer U. (2008). Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. Hum Mol Genet. 2008 Oct 15;17(20):3236-46