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Description
HDAC6 is a protein with 131 kDa. Has various molecular functions, such as dynein complex binding. Is involved in several biological processes, including cellular response to misfolded protein.
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Categories
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Details
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Complete Protein NameHistone deacetylase 6
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Gene ID10013
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Uniprot IDQ9UBN7
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Chromossomal LocationXp11.23
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RNA-binding proteinNo
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Molecular FunctionActin binding ,alpha-tubulin binding ,beta-catenin binding , beta-tubulin binding ,core promoter binding ,dynein complex binding ,enzyme binding , histone deacetylase activity ,histone deacetylase binding ,Hsp90 protein binding ,microtubule binding ,misfolded protein binding ,NAD-dependent histone deacetylase activity (H3-K14 specific) ,polyubiquitin binding ,tau protein binding ,tubulin deacetylase activity ,ubiquitin protein ligase binding ,zinc ion binding
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OMIM DiseaseChondrodysplasia
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Used cell typeHeLa, MEFs
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Used StimuliSodium arsenite, UV irradiation, CCCP, heat shock
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Subcellular LocalizationNucleus, Cytoplasm, Perikaryon, dendrite, axon
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ReferenceKwon,S.; Zhang,Y.; Matthias,P. (2007).The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 2007 Dec 15;21(24):3381-94