IFIH1

Interferon-induced helicase C domain-containing protein 1

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    Description

    IFIH1 is an Innate immune receptor with 116 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including cellular response to exogenous dsRNA.

     

     

     

     

     

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    Tags
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    Details
    • Complete Protein Name
      Interferon-induced helicase C domain-containing protein 1
    • Gene ID
      64135
    • Uniprot ID
      Q9BYX4
    • Chromossomal Location
      2q24.2
    • RNA-binding protein
      No
    • Molecular Function
      ATP binding ,DNA binding ,double-stranded RNA binding , helicase activity ,identical protein binding , ribonucleoprotein complex binding , single-stranded RNA binding ,zinc ion binding
    • OMIM Disease
      Aicardi-Goutieres syndrome, Singleton-Merten syndrome
    • Used cell type
      A549
    • Used Stimuli
      Heat shock, hippuristanol
    • Subcellular Localization
      Nucleus, Cytoplasm
    • Reference
      Zhang,P.; Li,Y.; Xia,J; He,J.; Pu, J.; Xie,J.; Wu,S.; Feng,L.; Huang,X.; Zhang,P.(2014). IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its ativation. J Cell Sci. 127(Pt 11):2471-82
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