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    IFIH1

    Interferon-induced helicase C domain-containing protein 1

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      Description

      IFIH1 is an Innate immune receptor with 116 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including cellular response to exogenous dsRNA.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Interferon-induced helicase C domain-containing protein 1
      • Gene ID
        64135
      • Uniprot ID
        Q9BYX4
      • Chromossomal Location
        2q24.2
      • RNA-binding protein
        No
      • Molecular Function
        ATP binding ,DNA binding ,double-stranded RNA binding , helicase activity ,identical protein binding , ribonucleoprotein complex binding , single-stranded RNA binding ,zinc ion binding
      • OMIM Disease
        Aicardi-Goutieres syndrome, Singleton-Merten syndrome
      • Used cell type
        A549
      • Used Stimuli
        Heat shock, hippuristanol
      • Subcellular Localization
        Nucleus, Cytoplasm
      • Reference
        Zhang,P.; Li,Y.; Xia,J; He,J.; Pu, J.; Xie,J.; Wu,S.; Feng,L.; Huang,X.; Zhang,P.(2014). IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its ativation. J Cell Sci. 127(Pt 11):2471-82
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