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    PARN

    Poly(A)-specific ribonuclease

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      Description

      PARN is a protein with 73 kDa (73,451 Da - isoform 1). It is a RNA binding protein and has hydrolase and catalytic activity on both the DNA and RNA. It is involved in the mRNA metabolic process, reproductive process and telemore organization.

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      Details
      • Complete Protein Name
        Poly(A)-specific ribonuclease
      • Gene ID
        5073
      • Uniprot ID
        O95453
      • Chromossomal Location
        16p13.12
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; transferase activity; hydroase activity; catalytic activity (acting on dna and rna)
      • OMIM Disease
        Dyskeratosis congenita, autosomal recessive 6; Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4
      • Used cell type
        HEK293T; iPSCs; HeLa; HepG2
      • Used Stimuli
        puromycin, thapsigargin, heat shock, sodium arsenite
      • Subcellular Localization
        nucleus; cytoplasm
      • Reference
        Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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