PARN

Poly(A)-specific ribonuclease

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    Description

    PARN is a protein with 73 kDa (73,451 Da - isoform 1). It is a RNA binding protein and has hydrolase and catalytic activity on both the DNA and RNA. It is involved in the mRNA metabolic process, reproductive process and telemore organization.

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    Details
    • Complete Protein Name
      Poly(A)-specific ribonuclease
    • Gene ID
      5073
    • Uniprot ID
      O95453
    • Chromossomal Location
      16p13.12
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; transferase activity; hydroase activity; catalytic activity (acting on dna and rna)
    • OMIM Disease
      Dyskeratosis congenita, autosomal recessive 6; Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4
    • Used cell type
      HEK293T; iPSCs
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus; cytoplasm
    • Reference
      Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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