DROSHA

Drosha ribonuclease III

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    Description

    DROSHA is a protein with 159 kDa (159,316 Da - isoform 1). It is a rna and lipid binding protein with hydrolase and catalytic activities. It is involved in immune system processes, dna-templated transcription, inflammatory response, snrna metabolic processes, cell differentiation, ribosome biogenesis, anatomical structure development and silencing of ncrna-mediated regulatory genes.

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    Categories
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    Details
    • Complete Protein Name
      Drosha ribonuclease III
    • Gene ID
      29102
    • Uniprot ID
      Q9NRR4
    • Chromossomal Location
      5p13.3
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; lipid binding; hydrolase activity; catalytic activity (acting on rna)
    • Used cell type
      HEK293T; iPSCs
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus (nucleolus)
    • Reference
      Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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