menu
Explore the database
search
search
    close

    DROSHA

    Drosha ribonuclease III

      view_headline
      Description

      DROSHA is a protein with 159 kDa (159,316 Da - isoform 1). It is a rna and lipid binding protein with hydrolase and catalytic activities. It is involved in immune system processes, dna-templated transcription, inflammatory response, snrna metabolic processes, cell differentiation, ribosome biogenesis, anatomical structure development and silencing of ncrna-mediated regulatory genes.

      view_module
      Categories
      view_module
      Tags
      view_module
      Details
      • Complete Protein Name
        Drosha ribonuclease III
      • Gene ID
        29102
      • Uniprot ID
        Q9NRR4
      • Chromossomal Location
        5p13.3
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; lipid binding; hydrolase activity; catalytic activity (acting on rna)
      • Used cell type
        HEK293T, iPSCs, HeLa, HepG2
      • Used Stimuli
        puromycin, thapsigargin, heat shock, sodium arsenite
      • Subcellular Localization
        nucleus (nucleolus)
      • Reference
        Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
      keyboard_arrow_up