DEAD-box helicase 3 X-linked


    DDX3X is a protein with 73 kDa (73,243 Da - isoform 1). It is a rna, dna and cytoskeletal binding protein with gtpase, transferase, hydrolase, molecular adaptor, molecular function regulator and atp-dependent activities. It also has catalytic activities acting on rna, dna and proteins. It is involved in several biological processes such as the mitotic cell cycle, immune system responses, regulation of dna-templated transcription, chromosome segregation, cell signaling and differentiation, and others.

    • Complete Protein Name
      DEAD-box helicase 3 X-linked
    • Gene ID
    • Uniprot ID
    • Chromossomal Location
    • RNA-binding protein
    • Molecular Function
      dna binding; rna binding; gtpase activity; cytoskeletal protein binding; transferase activity; hydrolase activity; molecular adaptor activity; molecular function regulator activity; catalytic activity (acting on dna, rna and protein); atp-dependent activity
    • OMIM Disease
      Intellectual developmental disorder, X-linked syndromic, Snijders Blok type
    • Used cell type
      HEK293T; HeLa
    • Used Stimuli
      sodium arsenite; UV irradiation
    • Subcellular Localization
      nucleus; cytoplasm (stress granules, centrosome); cell membrane
    • Reference
      Valentin-Vega YA, Wang YD, Parker M, Patmore DM, Kanagaraj A, Moore J, Rusch M, Finkelstein D, Ellison DW, Gilbertson RJ, Zhang J, Kim HJ, Taylor JP. Author Correction: Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation. Sci Rep. 2024 Jun 6;14(1):13009. doi: 10.1038/s41598-024-63662-z. Erratum for: Sci Rep. 2016 May 16;6:25996.