menu
Explore the database
search
search
    close

    DDX3X

    DEAD-box helicase 3 X-linked

      view_headline
      Description

      DDX3X is a protein with 73 kDa (73,243 Da - isoform 1). It is a rna, dna and cytoskeletal binding protein with gtpase, transferase, hydrolase, molecular adaptor, molecular function regulator and atp-dependent activities. It also has catalytic activities acting on rna, dna and proteins. It is involved in several biological processes such as the mitotic cell cycle, immune system responses, regulation of dna-templated transcription, chromosome segregation, cell signaling and differentiation, and others.

      view_module
      Categories
      view_module
      Tags
      view_module
      Details
      • Complete Protein Name
        DEAD-box helicase 3 X-linked
      • Gene ID
        1654
      • Uniprot ID
        O00571
      • Chromossomal Location
        Xp11.4
      • RNA-binding protein
        Yes
      • Molecular Function
        dna binding; rna binding; gtpase activity; cytoskeletal protein binding; transferase activity; hydrolase activity; molecular adaptor activity; molecular function regulator activity; catalytic activity (acting on dna, rna and protein); atp-dependent activity
      • OMIM Disease
        Intellectual developmental disorder, X-linked syndromic, Snijders Blok type
      • Used cell type
        HEK293T; HeLa
      • Used Stimuli
        sodium arsenite; UV irradiation
      • Subcellular Localization
        nucleus; cytoplasm (stress granules, centrosome); cell membrane
      • Reference
        Valentin-Vega YA, Wang YD, Parker M, Patmore DM, Kanagaraj A, Moore J, Rusch M, Finkelstein D, Ellison DW, Gilbertson RJ, Zhang J, Kim HJ, Taylor JP. Author Correction: Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation. Sci Rep. 2024 Jun 6;14(1):13009. doi: 10.1038/s41598-024-63662-z. Erratum for: Sci Rep. 2016 May 16;6:25996.
      keyboard_arrow_up