CDC20

Cell division cycle 20

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    Description

    CDC20 is a protein with almost 55 kDa (54,723 Da). It has molecular adapator and function regulator activities and transferase and catalytic activity. It is highly involved in the mitotic cell cycle and there is evidence of this protein involvement in cytoskeleton organization, chromosome seggregation, reproductive process, cell signaling and differentiation, and others.

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    Details
    • Complete Protein Name
      Cell division cycle 20
    • Gene ID
      991
    • Uniprot ID
      Q12834
    • Chromossomal Location
      1p34.2
    • RNA-binding protein
      No
    • Molecular Function
      transferase activity; molecular adaptor activity; molecular function regulator activity; catalytic activity (acting on protein)
    • OMIM Disease
      Oocyte/zygote/embryo maturation arrest 14
    • Used cell type
      U-2 OS cells
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      cytoplasm (cytoskeleton, centrosome), centromere
    • Reference
      Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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