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    BAZ1B

    Bromodomain adjacent to zinc finger domain 1B

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      Description

      BAZ1B is a protein with 170 kDa (170,903 Da - isoform 1). It has transferase and protein catalytic activity along with the capability of binding histones. It is involved in chromatin organization, regulation of dna-templated transcription, chromosome segregation and mitotic nuclear division.

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      Details
      • Complete Protein Name
        Bromodomain adjacent to zinc finger domain 1B
      • Gene ID
        9031
      • Uniprot ID
        Q9UIG0
      • Chromossomal Location
        7q11.23
      • RNA-binding protein
        No
      • Molecular Function
        transferase activity; histone binding; catalytic activity (acting on a protein)
      • Used cell type
        U-2 OS cells
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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