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    AMOTL2

    Angiomotin like 2

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      Description

      AMOTL2 is protein with almost 86 kDa (85,764 da).  It regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. It is important for the normal function and architecture of the actin filaments. It is involved in signalling pathways such as the Wnt/beta-catenin pathway. May play a role in the polarity, proliferation and migration of endothelial cells.

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      Details
      • Complete Protein Name
        Angiomotin like 2
      • Gene ID
        51421
      • Uniprot ID
        Q9Y2J4
      • Chromossomal Location
        3q22.2
      • RNA-binding protein
        No
      • Molecular Function
        None found on Uniprot
      • Used cell type
        U-2 OS cells
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        recycling endosome
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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